A Meta‐Analysis of Carbon Nanotube Pulmonary Toxicity Studies—How Physical Dimensions and Impurities Affect the Toxicity of Carbon Nanotubes
Identifieur interne : 004C79 ( Main/Exploration ); précédent : 004C78; suivant : 004C80A Meta‐Analysis of Carbon Nanotube Pulmonary Toxicity Studies—How Physical Dimensions and Impurities Affect the Toxicity of Carbon Nanotubes
Auteurs : Jeremy M. Gernand [États-Unis] ; Elizabeth A. Casman [États-Unis]Source :
- Risk Analysis [ 0272-4332 ] ; 2014-03.
Descripteurs français
- KwdFr :
- MESH :
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Carbon nanotubes, Evidence-based medicine, Human, Impurity, Inhalation, Lung, Lung (drug effects), Metaanalysis, Nanostructured materials, Nanotubes, Carbon (toxicity), Particle Size, Particle size, Probability, Regression Analysis, Regression analysis, Risk Assessment, Support Vector Machine, Toxicity, Toxicity test.
- MESH :
- chemical , toxicity : Nanotubes, Carbon.
- drug effects : Lung.
- Particle Size, Probability, Regression Analysis, Risk Assessment, Support Vector Machine.
Abstract
This article presents a regression‐tree‐based meta‐analysis of rodent pulmonary toxicity studies of uncoated, nonfunctionalized carbon nanotube (CNT) exposure. The resulting analysis provides quantitative estimates of the contribution of CNT attributes (impurities, physical dimensions, and aggregation) to pulmonary toxicity indicators in bronchoalveolar lavage fluid: neutrophil and macrophage count, and lactate dehydrogenase and total protein concentrations. The method employs classification and regression tree (CART) models, techniques that are relatively insensitive to data defects that impair other types of regression analysis: high dimensionality, nonlinearity, correlated variables, and significant quantities of missing values. Three types of analysis are presented: the RT, the random forest (RF), and a random‐forest‐based dose‐response model. The RT shows the best single model supported by all the data and typically contains a small number of variables. The RF shows how much variance reduction is associated with every variable in the data set. The dose‐response model is used to isolate the effects of CNT attributes from the CNT dose, showing the shift in the dose‐response caused by the attribute across the measured range of CNT doses. It was found that the CNT attributes that contribute the most to pulmonary toxicity were metallic impurities (cobalt significantly increased observed toxicity, while other impurities had mixed effects), CNT length (negatively correlated with most toxicity indicators), CNT diameter (significantly positively associated with toxicity), and aggregate size (negatively correlated with cell damage indicators and positively correlated with immune response indicators). Increasing CNT N2‐BET‐specific surface area decreased toxicity indicators.
Url:
DOI: 10.1111/risa.12109
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003155
- to stream Istex, to step Curation: 003155
- to stream Istex, to step Checkpoint: 000798
- to stream PubMed, to step Corpus: 003983
- to stream PubMed, to step Curation: 003957
- to stream PubMed, to step Checkpoint: 003957
- to stream Ncbi, to step Merge: 000270
- to stream Ncbi, to step Curation: 000270
- to stream Ncbi, to step Checkpoint: 000270
- to stream Main, to step Merge: 004F16
- to stream PascalFrancis, to step Corpus: 000890
- to stream PascalFrancis, to step Curation: 003D41
- to stream PascalFrancis, to step Checkpoint: 000D97
- to stream Main, to step Merge: 005D20
- to stream Main, to step Curation: 004C79
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Meta‐Analysis of Carbon Nanotube Pulmonary Toxicity Studies—How Physical Dimensions and Impurities Affect the Toxicity of Carbon Nanotubes</title>
<author><name sortKey="Gernand, Jeremy M" sort="Gernand, Jeremy M" uniqKey="Gernand J" first="Jeremy M." last="Gernand">Jeremy M. Gernand</name>
</author>
<author><name sortKey="Casman, Elizabeth A" sort="Casman, Elizabeth A" uniqKey="Casman E" first="Elizabeth A." last="Casman">Elizabeth A. Casman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:CFB9ADF5408CEC25EC46A94D8D48AF3A7CEFBC25</idno>
<date when="2014" year="2014">2014</date>
<idno type="doi">10.1111/risa.12109</idno>
<idno type="url">https://api.istex.fr/document/CFB9ADF5408CEC25EC46A94D8D48AF3A7CEFBC25/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003155</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003155</idno>
<idno type="wicri:Area/Istex/Curation">003155</idno>
<idno type="wicri:Area/Istex/Checkpoint">000798</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000798</idno>
<idno type="wicri:doubleKey">0272-4332:2014:Gernand J:a:meta:analysis</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:24024907</idno>
<idno type="wicri:Area/PubMed/Corpus">003983</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003983</idno>
<idno type="wicri:Area/PubMed/Curation">003957</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003957</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003957</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003957</idno>
<idno type="wicri:Area/Ncbi/Merge">000270</idno>
<idno type="wicri:Area/Ncbi/Curation">000270</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000270</idno>
<idno type="wicri:Area/Main/Merge">004F16</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:14-0176722</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000890</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003D41</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000D97</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000D97</idno>
<idno type="wicri:doubleKey">0272-4332:2014:Gernand J:a:meta:analysis</idno>
<idno type="wicri:Area/Main/Merge">005D20</idno>
<idno type="wicri:Area/Main/Curation">004C79</idno>
<idno type="wicri:Area/Main/Exploration">004C79</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">A Meta‐Analysis of Carbon Nanotube Pulmonary Toxicity Studies—How Physical Dimensions and Impurities Affect the Toxicity of Carbon Nanotubes</title>
<author><name sortKey="Gernand, Jeremy M" sort="Gernand, Jeremy M" uniqKey="Gernand J" first="Jeremy M." last="Gernand">Jeremy M. Gernand</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Engineering and Public Policy, Carnegie Mellon University, PA, Pittsburgh</wicri:regionArea>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université Carnegie-Mellon</orgName>
</affiliation>
</author>
<author><name sortKey="Casman, Elizabeth A" sort="Casman, Elizabeth A" uniqKey="Casman E" first="Elizabeth A." last="Casman">Elizabeth A. Casman</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Engineering and Public Policy, Carnegie Mellon University, PA, Pittsburgh</wicri:regionArea>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université Carnegie-Mellon</orgName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Risk Analysis</title>
<title level="j" type="alt">RISK ANALYSIS</title>
<idno type="ISSN">0272-4332</idno>
<idno type="eISSN">1539-6924</idno>
<imprint><biblScope unit="vol">34</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="583">583</biblScope>
<biblScope unit="page" to="597">597</biblScope>
<biblScope unit="page-count">15</biblScope>
<date type="published" when="2014-03">2014-03</date>
</imprint>
<idno type="ISSN">0272-4332</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0272-4332</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carbon nanotubes</term>
<term>Evidence-based medicine</term>
<term>Human</term>
<term>Impurity</term>
<term>Inhalation</term>
<term>Lung</term>
<term>Lung (drug effects)</term>
<term>Metaanalysis</term>
<term>Nanostructured materials</term>
<term>Nanotubes, Carbon (toxicity)</term>
<term>Particle Size</term>
<term>Particle size</term>
<term>Probability</term>
<term>Regression Analysis</term>
<term>Regression analysis</term>
<term>Risk Assessment</term>
<term>Support Vector Machine</term>
<term>Toxicity</term>
<term>Toxicity test</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de régression</term>
<term>Machine à vecteur de support</term>
<term>Nanotubes de carbone (toxicité)</term>
<term>Poumon ()</term>
<term>Probabilité</term>
<term>Taille de particule</term>
<term>Évaluation des risques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Nanotubes, Carbon</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Nanotubes de carbone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Particle Size</term>
<term>Probability</term>
<term>Regression Analysis</term>
<term>Risk Assessment</term>
<term>Support Vector Machine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de régression</term>
<term>Machine à vecteur de support</term>
<term>Poumon</term>
<term>Probabilité</term>
<term>Taille de particule</term>
<term>Évaluation des risques</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Analyse régression</term>
<term>Dimension particule</term>
<term>Homme</term>
<term>Impureté</term>
<term>Inhalation</term>
<term>Médecine factuelle</term>
<term>Métaanalyse</term>
<term>Nanomatériau</term>
<term>Nanotube carbone</term>
<term>Poumon</term>
<term>Test toxicité</term>
<term>Toxicité</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">This article presents a regression‐tree‐based meta‐analysis of rodent pulmonary toxicity studies of uncoated, nonfunctionalized carbon nanotube (CNT) exposure. The resulting analysis provides quantitative estimates of the contribution of CNT attributes (impurities, physical dimensions, and aggregation) to pulmonary toxicity indicators in bronchoalveolar lavage fluid: neutrophil and macrophage count, and lactate dehydrogenase and total protein concentrations. The method employs classification and regression tree (CART) models, techniques that are relatively insensitive to data defects that impair other types of regression analysis: high dimensionality, nonlinearity, correlated variables, and significant quantities of missing values. Three types of analysis are presented: the RT, the random forest (RF), and a random‐forest‐based dose‐response model. The RT shows the best single model supported by all the data and typically contains a small number of variables. The RF shows how much variance reduction is associated with every variable in the data set. The dose‐response model is used to isolate the effects of CNT attributes from the CNT dose, showing the shift in the dose‐response caused by the attribute across the measured range of CNT doses. It was found that the CNT attributes that contribute the most to pulmonary toxicity were metallic impurities (cobalt significantly increased observed toxicity, while other impurities had mixed effects), CNT length (negatively correlated with most toxicity indicators), CNT diameter (significantly positively associated with toxicity), and aggregate size (negatively correlated with cell damage indicators and positively correlated with immune response indicators). Increasing CNT N2‐BET‐specific surface area decreased toxicity indicators.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université Carnegie-Mellon</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Gernand, Jeremy M" sort="Gernand, Jeremy M" uniqKey="Gernand J" first="Jeremy M." last="Gernand">Jeremy M. Gernand</name>
</region>
<name sortKey="Casman, Elizabeth A" sort="Casman, Elizabeth A" uniqKey="Casman E" first="Elizabeth A." last="Casman">Elizabeth A. Casman</name>
<name sortKey="Casman, Elizabeth A" sort="Casman, Elizabeth A" uniqKey="Casman E" first="Elizabeth A." last="Casman">Elizabeth A. Casman</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004C79 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004C79 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Amérique |area= PittsburghV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:CFB9ADF5408CEC25EC46A94D8D48AF3A7CEFBC25 |texte= A Meta‐Analysis of Carbon Nanotube Pulmonary Toxicity Studies—How Physical Dimensions and Impurities Affect the Toxicity of Carbon Nanotubes }}
This area was generated with Dilib version V0.6.38. |